The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 1997
Filed:
Nov. 22, 1994
Stanley M Goldin, Lexington, MA (US);
Subbarao Katragadda, Belmont, MA (US);
Lain-Yen Hu, Bedford, MA (US);
N Laxma Reddy, Malden, MA (US);
James B Fischer, Cambridge, MA (US);
Andrew Gannett Knapp, Salem, MA (US);
Lee David Margolin, Belmont, MA (US);
Cambridge NeuroScience, Inc., Cambridge, MA (US);
Abstract
Modulators of neurotransmitter release including substituted guanidines, N'-aminoguanidines, and N,N'N',N''-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.