The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 1997
Filed:
Oct. 12, 1994
Applicant:
Inventors:
Daniel F Veber, Ambler, PA (US);
S Dale Lewis, Lansdale, PA (US);
Jules A Shafer, Gwynedd Valley, PA (US);
Dong-Mei Feng, Harleysville, PA (US);
Ruth F Nutt, San Diego, CA (US);
Stephen F Brady, Philadelphia, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
514 19 ; 514 18 ; 530331 ; 424 9464 ; 562445 ; 548535 ;
Abstract
4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailability. They have the formula ##STR1## for example ##STR2##