The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 1997
Filed:
Mar. 18, 1996
Applicant:
Inventors:
Henri Brunengraber, Shaker Heights, OH (US);
Hermann Dugas, Montreal, CA;
Khadija Quinze, Villeurbanne, FR;
Catherine Bomont, Cleveland, OH (US);
Assignee:
Case Western Reserve University, Cleveland, OH (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C / ; A01N / ;
U.S. Cl.
CPC ...
435-12 ; 560155 ;
Abstract
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia. The novel pyruvate compound is particularly a pyruvate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is an N-acetyl ethyl ester of the cysteine or methionine amino acid. The most preferred compound is: ##STR1##