The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 1997
Filed:
May. 15, 1992
Gregory A Kopia, Phoenixville, PA (US);
Paul K Horan, Downingtown, PA (US);
Brian D Gray, Ardmore, PA (US);
David E Troutner, Phoenixville, PA (US);
Katharine A Muirhead, West Chester, PA (US);
Kamleshkumar A Sheth, Downingtown, PA (US);
Chia-En Lin, Norristown, PA (US);
Zhizhou Yu, Jeffersonville, PA (US);
Bruce D Jensen, Collegeville, PA (US);
Sue Ellen Slezak, Downingtown, PA (US);
Zynaxis, Inc., Malvern, PA (US);
Abstract
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site. Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.