The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 1997
Filed:
Apr. 11, 1995
Donald F Wallach, Hollis, NH (US);
Carole Varanelli, Chester, NH (US);
Micro-Pak, Inc., Wilmington, DE (US);
Abstract
A method for transmitting a biologically active material to a cell is provided. The method involves encapsulating the material to be transmitted in a paucilamellar non-phospholipid carrier vesicle which does not lyse cells upon fusion with cells, delivering the carrier vesicle to a location proximate to the cell, allowing the non-phospholipid bilayer of the carrier vesicle to fuse with the membrane of the cell and allowing the encapsulated material to diffuse into the cell. The method can be used to transmit a variety of biologically active materials to cells either in vitro or in vivo. The method provides a means for transmitting a biologically active material directly to the cytoplasm of a cell. Upon fusion with a cell, material associated with the bilayers of the non-phospholipid vesicle becomes incorporated into the outer membrane of the cell. Accordingly, a method for transmitting bilayer-associated material to a cell is also provided.