The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 1997
Filed:
Feb. 16, 1995
Applicant:
Inventors:
Rainer Obermeier, Hattersheim, DE;
Martin Gerl, Kriftel, DE;
Jurgen Ludwig, Brachttal, DE;
Walter Sabel, Bad Camberg, DE;
Assignee:
Hoechst Aktiengesellschaft, Frankfurt am Main, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C12P / ;
U.S. Cl.
CPC ...
530303 ; 435 681 ; 530305 ;
Abstract
A process for obtaining insulin having correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan, chaotropic auxiliaries and at a pH of 10 to 11 is described, as well as the direct conversion of the proinsulin to insulin with the aid of enzymes and direct isolation of the insulin from the reaction mixture with the aid of hydrophobic adsorber resins.