The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 1997
Filed:
Aug. 08, 1994
Dora Yuk-wai Ho, Mountain View, CA (US);
Robert Morris Sapolsky, San Francisco, CA (US);
Edward S Mocarski, Jr, Menlo Park, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Defective herpes simplex virus (HSV) vectors have been used to express a glucose transporter gene. The vectors were propagated using HSV conditional mutants. The efficacy of this system in vivo was tested by microinjection of the vector into adult rat hippocampus and measurement with [.sup.14 C]2-deoxyglucose uptake autoradiography, as well as measurement of kainic acid-(KA-) induced lesions. The vector significantly enhanced glucose transport and decreased neuronal damage in regions near the site of injection without causing adverse cytopathology. Neuroprotection was conferred by injecting the vector prior to, concurrently with, and following neuronal insult.