The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 1997
Filed:
May. 16, 1995
Applicant:
Inventors:
Philip John Burke, Charlton, GB;
Robert Ian Dowell, Congleton, GB;
Anthony Brian Mauger, Kensington, MD (US);
Assignees:
Zeneca Limited, London, GB;
Cancer Research Campaign Technology, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C07C / ; C07F / ;
U.S. Cl.
CPC ...
4241781 ; 4241821 ; 514476 ; 560134 ; 560135 ; 560136 ; 560137 ;
Abstract
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.