The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 1997
Filed:
Dec. 22, 1994
Kyunghye Ahn, Ann Arbor, MI (US);
Xue-Min Cheng, Ann Arbor, MI (US);
Annette Marian Doherty, Ann Arbor, MI (US);
Edward Faith Elslager, Ann Arbor, MI (US);
Brian Kornberg, Ann Arbor, MI (US);
Chitase Lee, Ann Arbor, MI (US);
Daniele Leonard, Ann Arbor, MI (US);
Sham Nikam, Ann Arbor, MI (US);
Leslie Morton Werbel, Ann Arbor, MI (US);
Warner-Lambert Company, Morris Plains, NJ (US);
Abstract
Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.