The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 1997
Filed:
Mar. 30, 1995
Krysztof W Pankiewicz, Bronxville, NY (US);
Kyoichi A Watanabe, Rye-Brook, NY (US);
Andrzej Zatorski, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
This invention provides a compound having the structure: ##STR1## wherein each R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is independently fluorine, OH or H; Z is O, CH.sub.2 or CF.sub.2 ; each Y is independently OH or F; X.sub.7 is N or CH, X.sub.8 is NH, S or Se; and W is C or N, wherein when W is C, the dashed line (---) represents a double bond and X.sub.9 is N or CH, and wherein when W is N, the dashed line (---) represents a single bond and X.sub.9 is S or Se, or the dashed line (---) represents a double bond and X.sub.9 is N or CH. This invention also provides a pharmaceutical composition comprising the compounds and methods of treating a mammal having an inosine monophosphate dehydrogenase associated disorder.