The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 1997
Filed:
Dec. 14, 1994
Applicant:
Inventors:
Harry E Gruber, San Diego, CA (US);
Ronald R Tuttle, Escondido, CA (US);
Clinton E Browne, Oceanside, CA (US);
Bheemarao G Ugarkar, Escondido, CA (US);
Jack W Reich, Carlsbad, CA (US);
Ernest K Metzner, Del Mar, CA (US);
Paul J Marangos, Encinitas, CA (US);
Assignee:
Gensia Pharmaceuticals, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
514 43 ; 514 45 ; 514 46 ; 514866 ;
Abstract
AICA riboside and prodrugs of AICA riboside are provided which lower blood glucose for the treatment of various pathologic conditions, including hypoglycemia, insulin deficiency, insulin resistance diabetes and Syndrome X. Prodrugs of AICA riboside provide AICA riboside in an orally bioavailable form. The use of adenosine kinase inhibition and ZMP enhancement for lowering blood glucose are also described.