The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 1997
Filed:
Jun. 24, 1994
Applicant:
Inventors:
Timothy R Billiar, Pittsburgh, PA (US);
Edith Tzeng, Pittsburgh, PA (US);
Andreas K Nussler, Neu-Ulm, DE;
David A Geller, Pittsburgh, PA (US);
Richard L Simmons, Pittsburgh, PA (US);
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
424 9321 ; 424 932 ; 424 931 ; 514 44 ; 435189 ; 435191 ; 4353201 ; 4351723 ; 4352351 ; 536 231 ; 536 232 ; 536 235 ; 935 60 ; 935 22 ; 935 32 ; 935-9 ;
Abstract
The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed invention, iNOS-directed gene therapy involves specific targeting of a DNA sequence encoding a protein or protein fragment with iNOS biological activity for treating vascular diseases and disorders, antitumor applications and in response to certain microbial infections.