The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 1997
Filed:
Sep. 17, 1993
Applicant:
Inventors:
Norbert Bischofberger, San Carlos, CA (US);
Robert J Jones, Millbrae, CA (US);
Murty Arimilli, Fremont, CA (US);
Kuei-Ying Lin, Fremont, CA (US);
Michael Louie, Burlingame, CA (US);
Lawrence R McGee, Pacifica, CA (US);
Ernest J Prisbe, Los Altos, CA (US);
Assignee:
Gilead Sciences, Inc., Foster City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
536 2534 ; 536 2714 ; 536 2721 ; 536 276 ; 536 277 ; 536 278 ; 536 2781 ; 536 282 ; 536 285 ; 536 2851 ; 536 2852 ; 536 2853 ; 536 2854 ; 536 2855 ; 544242 ; 544243 ; 544244 ; 544264 ; 544265 ; 544267 ; 544303 ; 544304 ; 544310 ;
Abstract
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.