The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 1997
Filed:
Jul. 26, 1994
Yoshitake Terano, Ikeda, JP;
Hiroshi Nakazato, Ibaraki, JP;
Suntory Limited, Osaka, JP;
Abstract
The present invention provides monoclonal antibodies that specifically recognize a specific structural portion of cardiac glycoside. The monoclonal antibodies of the present invention recognize an integrated structure in the steroid structure of cardiac glycoside or its aglycon comprising: a D-ring bonded in the cis-configuration with respect a C-ring; a methyl group bonded in the .beta.-configuration at the C13 position; a hydroxyl group bonded in the .beta.-configuration at the C14 position; and, an .alpha., .beta.-unsaturated lactone group bonded in the .beta.-configuration at the C17 position. This structure is common to cardiac glycoside substances that inhibit potassium ion concentration antagonist type Na.sup.+,K.sup.+ -ATPase.