The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 1997
Filed:
Jul. 15, 1996
Rene C Gaudreault, Bernieres, CA;
Claude Gicquaud, Trois-Rivieres, CA;
Patrick Poyet, St-Redempteur, CA;
Universite Laval, Quebec, CA;
Abstract
Carriers for pharmacologic agents comprise nanoerythrosomes, which are vesicles prepared by the extrusion of red blood cell ghosts, the average diameter of these vesicles is 0.1 .mu.m; the daunorubicin was covalently linked to nanoerythrosomes and the cytotoxicity of daunorubicin conjugated to nanoerythrosomes was assessed on P388D.sub.1 cell line; the results indicated that the cytotoxicity of conjugated daunorubicin was higher than the free daunorubicin, similar results were observed on CDF.sub.1 mice bearing grafted P388D.sub.1 leukemia tumors; daunorubicin-nanoerythrosome conjugates had a higher antineoplastic activity than the free bioactive agent.