The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 1997
Filed:
Sep. 23, 1994
David Parker, Durham, GB;
Nigel Robert Beeley, Thame, GB;
Celltech Therapeutics Limited, Slough, GB;
Abstract
##STR1## Metal complex of tetra-aza macrocycles of formula (1) wherein Alk.sup.1, Alk.sup.2, Alk.sup.3 and Alk.sup.4, which may be the same or different, is each a C.sub.1-4 alkylene chain optionally substituted by one or more optionally substituted C.sub.1-6 alkyl groups; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different is each a hydrogen atom or a group AlkR.sup.5 where Alk is an optionally substituted straight or branched C.sub.1-6 alkyl group and R.sup.5 is a hydrogen atom or a --CO.sub.2 H,--CONR.sup.6 R.sup.7 [where R.sup.6 and R.sup.7, which may be the same or different, is each a hydrogen atom or a C.sub.1-6 alkyl group] or --P(X.sup.1)(X.sup.2 R.sup.8)R.sup.9 group where X.sup.1 and X.sup.2, which may be the same or different is each an oxygen or sulphur atom, R.sup.8 is a hydrogen atom or an alkyl group and R.sup.9 is an aliphatic, aromatic or heteroaromatic group, with the proviso that at least two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group -AlkP(X.sup.1)(X.sup.2 R.sup.8)R.sup.9 or one or R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group -AlkP(X.sup.1)(X.sup.2 R.sup.8)R.sup.9 and at least one of the remaining groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group -AlkCO.sub.2 H or -AlkCONR.sup.6 R.sup.7, or a salt thereof, for use as contrast agents in nuclear magnetic resonance imaging are described.