The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 1997

Filed:

Jan. 25, 1995
Applicant:
Inventor:

Shlomo Margel, Rehovot, IL;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B32B / ;
U.S. Cl.
CPC ...
428403 ; 428402 ; 428327 ;
Abstract

A composition of matter includes a solid substrate having covalent bonds, provided by a connecting ligand, to at least one of (a) and (b), namely: (a) a single layer of at least one species of microspheres containing residual reactive functions; (b) a multiplicity of layers of at least one species of microspheres, wherein adjoining layers of multiplicity of layers are covalently linked together, the innermost layer of the multiplicity of layers having the covalent bonds to the solid substrate connected thereto, while at least the outermost layer of the multiplicity of layers contains residual reactive functions; the species of microspheres being selected from microspheres of silica, polyacrylic acid, polyglutaraldehyde, polyacrolein, poly(chloromethylated styrene) and albumin. At least some of the residual reactive functions may be used to immobilize drugs, prodrugs, proteins, biological cells and other controllably releasable substances.


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