The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 1997
Filed:
Aug. 28, 1995
Applicant:
Inventors:
Patrick Roussel, Thiais, FR;
Michel Vivat, Lagny Sur Marne, FR;
Assignee:
Roussel Uclaf, , FR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07J / ; C07J / ; C07J / ; C07J / ;
U.S. Cl.
CPC ...
552611 ; 540-7 ; 540 46 ; 552607 ; 552531 ;
Abstract
The invention is drawn to a process for the preparation of oxoetiocholenic acid of the formula I ##STR1## by reacting a compound of the formula II ##STR2## with a halonitrile in the presence of a base followed by formation of a 3-ketone group. The intermediate formed is reacted with an acid of the formula HX in an anhydrous medium followed by dehydrohalogenation of the resulting compound in the presence of a base. The intermediate produced then undergoes alkaline hydrolysis followed by a conventional acid treatment to obtain the compound of formula I.