The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 22, 1997

Filed:

Mar. 31, 1995
Applicant:
Inventors:

Andrea Leone-Bay, Ridgefield, CT (US);

Koc-Kan Ho, Mt. Kisco, NY (US);

Jeffery Bruce Press, Brewster, NY (US);

Assignee:

Emisphere Technologies, Inc., Hawthorne, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07C / ;
U.S. Cl.
CPC ...
514-2 ; 427 852 ; 427 854 ; 4271411 ; 4271841 ; 514-3 ; 514 11 ; 514 12 ; 514 21 ; 514 56 ; 514773 ; 514789 ; 562444 ; 562450 ;
Abstract

Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups have a variety of substituents including but not limited to hydroxy, methyl, fluoro, chloro, and the like. The compounds of the invention can be combined with numerous active agents including but not limited to heparin, peptides, and parathyroid hormone, and can then be used for effective administration of the active agent. Administration can be, for example, oral or parenteral.


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