The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 1997
Filed:
Aug. 06, 1993
Applicant:
Inventors:
James David Winkler, Fort Washington, PA (US);
Floyd Harold Chilton, III, Pilot Mountain, NC (US);
Deirdre Mary Hickey, Welwyn, GB;
Assignees:
SmithKline Beecham Corporation, Philadelphia, PA (US);
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
514398 ; 514359 ; 514374 ; 514392 ; 514397 ; 514406 ; 514425 ; 514825 ; 514826 ; 514863 ; 514916 ; 514921 ;
Abstract
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.