The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 08, 1997

Filed:

Oct. 04, 1991
Applicant:
Inventors:

John W Barnwell, New York, NY (US);

Mary R Galinski, New York, NY (US);

Assignee:

New York University, New York, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
530350 ; 4241911 ; 4241921 ; 435 693 ; 536 235 ;
Abstract

Disclosed are compounds comprising an amino acid sequence selected from the group consisting of malarial merozoite proteins located at the apical end of merozoites and peptides the peptides comprising synthetic versions, derivatives, analogs and fragments of the merozoite proteins. Certain of these compounds have the property of binding to a Duffy blood group antigen from primate red blood cells. Disclosed are also nucleic acids comprising a nucleotide sequence encoding such peptides or proteins and nucleic acids hybridizing therewith. The compounds and antibodies recognizing these compounds are useful in inhibiting invasion of susceptible primate red blood cells by malarial merozoites.


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