The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 1997
Filed:
Dec. 22, 1992
Ben K Seon, Williamsville, NY (US);
Health Research, Inc., Buffalo, NY (US);
Abstract
Three monoclonal antibodies defining extracellular epitopes of a unique heterodimeric glycoprotein complex consisting of the human mb-1 protein and the human B29 protein which react with one or more leukemia lymphoma cell specimens selected from the group consisting of B prolymphocytic leukemia cells, B non-Hodgkin's lymphoma cells, B chronic lymphocytic leukemia cells, B hairy cell leukemia cells, and B acute lymphoblastic leukemia cells. The three monoclonal antibodies also react with human non-malignant B cells. The invention also provides a method for producing the new monoclonal antibodies and for diagnostic procedures using the monoclonal antibodies and for the treatment of leukemia-lymphoma patients and patients with immunological diseases. The invention also relates to the isolation and chemical identification of the human B29 and mb-1 proteins of B cell antigen receptor complex. The amino-terminal amino acid sequences of the mb-1 and B29 gene products were determined.