The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 1997
Filed:
May. 03, 1994
Yu Yamaguchi, San Diego, CA (US);
Motoyuki Shimonaka, San Diego, CA (US);
La Jolla Cancer Research Foundation, Ja Jolla, CA (US);
Abstract
The present invention provides a substantially purified polypeptide, epitaxin, which is produced by fibroblasts and can stimulate migration of and DNA synthesis in a tumor cell. The invention also provides antibodies that are specifically reactive with epitaxin and cell lines that produce such antibodies. The invention also provides an active fragment antagonist of ETX activity, which can reduce or inhibit at least one activity of ETX. The invention further provides a method for controlling tumor cell migration and a method for controlling DNA synthesis in a tumor cell, comprising contacting the tumor cell with a composition of the invention. The invention also provides a method of increasing the sensitivity of a tumor cell to a cancer therapeutic agent.