The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 1997
Filed:
Dec. 13, 1994
Hans-Friedrich Vahlensieck, Basel, CH;
Albert Hinnen, Jena, DE;
Novartis Corporation, Tarrytown, NY (US);
Abstract
The present invention discloses DNA molecules comprising a gene encoding yeast acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Mutations confering soraphen A resistance to acetyl-CoA carboxylase can be dominant or recessive, and they can be point mutations, deletion or insertion mutations. In addition methods of isolating a gene encoding fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition are provided as well as methods for purifying fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Purified enzyme can be used in assays to identify inhibitors of soraphen A resistant acetyl-coenzyme A carboxylase.