The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1997
Filed:
Mar. 03, 1994
Applicant:
Inventors:
Ian Garner, Edinburgh, GB;
Michael L Dalrymple, Edinburgh, GB;
Donna E Prunkard, Seattle, WA (US);
Donald C Foster, Seattle, WA (US);
Assignees:
Pharmaceutical Proteins Ltd., Edinburgh, GB;
ZymoGenetics, Inc., Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12P / ;
U.S. Cl.
CPC ...
800-2 ; 435 691 ; 435 696 ; 435 697 ; 435 698 ; 435 711 ; 4351723 ; 514 44 ; 800D / ; 800D / ; 800D / ; 935 47 ; 935 48 ; 935 53 ; 935 55 ; 935 70 ;
Abstract
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A.alpha., B.beta. and .gamma. chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.