The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1997
Filed:
May. 25, 1995
Applicant:
Inventors:
Dennis Powell, Peekskill, NY (US);
Rolf Paul, River Vale, NJ (US);
William A Hallett, New City, NY (US);
Dan M Berger, Orangeburg, NY (US);
Minu D Dutia, West Nyack, NY (US);
Assignee:
American Cyanamid Company, Madison, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ;
U.S. Cl.
CPC ...
546293 ; 546290 ; 546302 ; 556427 ; 549369 ; 549374 ; 560-9 ; 564340 ; 564 54 ; 558411 ; 558418 ; 558423 ; 558425 ; 568 38 ; 568 45 ; 568 49 ; 568 56 ;
Abstract
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.