The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1997
Filed:
Feb. 02, 1995
Ronnie C Mease, Fairfax, VA (US);
Leonard F Mausner, Stony Brook, NY (US);
Suresh C Srivastava, Setauket, NY (US);
Associated Universities, Inc., Washington, DC (US);
Abstract
A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N',N''-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N',N''-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.