The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1997
Filed:
Mar. 24, 1995
Applicant:
Inventors:
Celia Dominguez, Newark, DE (US);
Joseph Cacciola, Newark, DE (US);
John Matthew Fevig, New London, PA (US);
Assignee:
The DuPont Merck Pharmaceutical Company, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07F / ; C07F / ; C07K / ;
U.S. Cl.
CPC ...
514 64 ; 514 18 ; 514 19 ; 530331 ; 544 60 ; 544 69 ; 544229 ; 546 13 ; 548110 ;
Abstract
The present invention relates generally to .alpha.-aminoboronic acids and corresponding peptide analogs of the formula (I): ##STR1## in which the .alpha.-carbon is substituted with an optionally functionalized imidazole containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes, especially thrombin, Factor X and Factor VII.