The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 1997
Filed:
Jun. 06, 1995
Thomas Bo Kjeldsen, Kv.ae butted.devej, DK;
Knud Vad, Frederiksberg, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention relates to a DNA expression cassette comprising the following sequence: 5'-P-SP-LS-PS-*gene*-(T).sub.i -3' wherein P is a promoter sequence, SP is a DNA sequence encoding a signal peptide, LS is a DNA sequence encoding a leader peptide of formula I: GinProIle(Asp/Glu)(Asp/Glu)X.sup.1 (Glu/Asp)X.sup.2 AsnZ(Thr/Ser)X.sup.3 (SEQ ID NO: 77) (I) wherein X.sup.1 is a peptide bond or a codable amino acid; X.sup.2 is a peptide bond, a codable amino acid or a sequence of up to 4 codable amino acids which may be the same or different; Z is a codable amino acid except Pro; and X.sup.3 is a sequence of from 4 to 30 codable amino acids which may be the same or different; PS is a DNA sequence encoding a processing site; *gene* is a DNA sequence encoding a polypeptide; T is a terminator sequence; and i is 0 or 1.