The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 1997
Filed:
Feb. 23, 1994
Applicant:
Inventors:
Phillip D Cook, Carlsbad, CA (US);
Oscar Acevedo, San Diego, CA (US);
Normand Hebert, San Marcos, CA (US);
Assignee:
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C07H / ; C07D / ;
U.S. Cl.
CPC ...
536 231 ; 536 243 ; 536 245 ; 536 253 ; 544242 ; 544264 ; 568-8 ; 568 11 ; 568 36 ;
Abstract
Compounds are provided having the structure: ##STR1## wherein the L groups are spanner or linker units, the Y and T group are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step.