The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 1997

Filed:

Mar. 18, 1993
Applicant:
Inventors:

Nils-Erik Anden, Sp.ang.nga, SE;

Berit C Backlund Hook, Uppsala, SE;

Anna L Bjork, Uppsala, SE;

Uli A Hacksell, Uppsala, SE;

Sven-Erik Hillver, Uppsala, SE;

Ye Liu, Uppsala, SE;

Eva C Mellin, Uppsala, SE;

Eva M Persson, Uppsala, SE;

Karl J Vallgang.rda, Uppsala, SE;

Hong Yu, Uppsala, SE;

Assignee:

Astra Aktiebolag, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514657 ; 514427 ; 514429 ; 514438 ; 514461 ; 5142265 ; 514255 ; 514278 ; 514319 ; 514326 ; 514328 ; 514412 ; 514414 ; 514415 ; 544 33 ; 544392 ; 546 16 ; 546 19 ; 546205 ; 546206 ; 546207 ; 546208 ; 546212 ; 546213 ; 546214 ; 548517 ; 548525 ; 548465 ; 5483647 ; 5483641 ; 5483657 ; 5483651 ; 5483615 ; 5483625 ; 5483061 ; 5483051 ; 5483121 ; 5483147 ; 549 80 ; 549504 ; 564374 ; 564428 ;
Abstract

A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR.sup.1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein R is hydrogen or C.sub.1 -methyl (cis-configuration), R.sup.1 is C.sub.1 -C.sub.6 alkyl or an aromatic ring which may contain heteroatoms selected from O and S and may be substituted or fused to an optionally substituted benzene ring, R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.3 may be different groups defined in claim 1, and enantiomers/salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds.


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