The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 1997

Filed:

Nov. 16, 1993
Applicant:
Inventors:

Herman A DeBoer, Roelofarendsveen, NL;

Rein Strijker, Oegstgeest, NL;

Herbert L Heyneker, Hillsborough, CA (US);

Gerard Platenburg, Voorschoten, NL;

Sang H Lee, Leiden, NL;

Frank Pieper, Utrecht, NL;

Paul J Krimpenfort, Heemstede, NL;

Assignee:

Pharming BV, Lieden, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ;
U.S. Cl.
CPC ...
4351723 ; 800-2 ; 935 52 ; 935 53 ;
Abstract

A method is disclosed for the production of a transgenic bovine or a transgenic bovine embryo comprising obtaining an ovum from bovine ovaries, maturing the ovum in vitro, fertilizing the mature ovum or ova in vitro to form a zygote, introducing a transgene into the zygote in vitro and maturing the zygote to a preimplantation stage embryo in vitro. To produce the transgenic bovine, the embryo is transplanted into a recipient female bovine, wherein the female bovine gestates the embryo to produce a transgenic bovine.


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