The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 1997
Filed:
Sep. 23, 1994
Applicant:
Inventors:
Victor E Marquez, Gaithersburg, MD (US);
Juan B Rodriguez, Buenos Aires, AR;
Marc C Nicklaus, Elkridge, MD (US);
Joseph J Barchi, Jr, Bethesda, MD (US);
Maqbool A Siddiqui, Rockville, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; C07C / ; C07D / ;
U.S. Cl.
CPC ...
568327 ; 568660 ; 568665 ; 568667 ; 568323 ; 568324 ; 544243 ; 544244 ; 544276 ; 544277 ; 544314 ; 544317 ; 544264 ; 536 221 ; 536 231 ; 536 2612 ; 536 2613 ; 536 2614 ;
Abstract
Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.