The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 1997
Filed:
Aug. 09, 1994
C Frank Bennett, Carlsbad, CA (US);
David S Grass, Lawrenceville, NJ (US);
Mark E Swanson, Princeton Junction, NJ (US);
DNX Biotherapeutics, Princeton, NJ (US);
Abstract
The present invention concerns transgenic animals that express an abnormaly high level of phospholipase A.sub.2 in their serum, liver, lung, kidney and skin. More particularly rats and mice expressing human non-pancreatic, low molecular weight phospholipase A.sub.2 are disclosed. Although transfected with a normal human gene, the animals develop a variety of pathological signs and produce the enzyme ectopically. The animals of the invention are useful for the testing of compounds to determine whether the compounds possess in vivo activity as phospholipase inhibitors or antagonists suitable for pharmacolgic use.