The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 1997
Filed:
Feb. 13, 1995
Terumi Kohwi-Shigematsu, San Diego, CA (US);
Yoshinori Kohwi, San Diego, CA (US);
The Burnham Institute, La Jolla, CA (US);
Abstract
The present invention provides a substantially purified protein, p114-MBP, which has an apparent molecular mass of about 114 kDa and specifically associates with a matrix attachment region DNA sequence context (MAR). p114-MBP is characterized, in part, by having substantial MAR binding activity in malignant tumor tissue but not in a corresponding non-cancerous tissue. The invention also provides a method of detecting the presence of malignant tumor tissue in a cell sample suspected of containing malignant tumor tissue by contacting the sample with a MAR, under conditions that allow the specific association of the MAR with p114-MBP, and detecting such specific association, which indicates the presence of malignant tumor tissue in the cell sample. The present invention further provides a method of diagnosing cancer in a subject suspected of having cancer by contacting a cell sample obtained from a subject with a MAR under conditions that allow the specific association of the MAR with p114-MBP and detecting such specific association, which indicates that malignant tumor tissue was present in the sample and, therefore, is diagnostic of cancer in the subject. The invention also provides a method of determining the prognosis of a cancer patient.