The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 1997
Filed:
May. 23, 1994
Wendelin Frick, Frankfur am Main, DE;
G unter M uller, Sulzbach am Taunus, DE;
Stefan M ullner, Hochheim am Main, DE;
Gerhard Breipohl, Frankfurt am Main, DE;
Hoechst Aktiengesellschaft, Frankfurt am Main, DE;
Abstract
Peptides with an insulin-like action, of formula I: ##STR1## in which G is a hydrogen atom, an amino add residue, or a monosubstituted or polysubstituted amino acid; D is an amino acid residue, a phosphoamino acid residue, a monosaccharide residue, or a covalent bond; E is --NH--(CH.sub.2).sub.n --NR.sup.5.sub.2, a glycerol residue, or --NH--(CH.sub.2).sub.p --R.sup.6 --R.sup.7 ; R.sup.1 is (C.sub.1 -C.sub.4)-alkyl or .dbd.O; R.sup.2 is a sulfhydryl protecting group, (C.sub.1 -C.sub.3)-alkyl, or a hydrogen atom; R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or methyl; R.sup.5, each being identical or different, is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; R.sup.6 is O PO.sub.4 H, PO.sub.2 H, NHCOO, S or OCOO; R.sup.7 is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; w is an integer 1 or 2; their preparation and use for treatment of diabetes mellitus or insulin-independent diabetes.