The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 1997
Filed:
Dec. 19, 1994
Applicant:
Inventors:
Say-Jong Law, Westwood, MA (US);
Hana Lukinsky, Mansfield, MA (US);
Assignee:
Ciba Corning Diagnostics Corp., Medfield, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C12P / ; C07H / ; C12N / ;
U.S. Cl.
CPC ...
435-6 ; 435 911 ; 435879 ; 435968 ; 536 231 ; 536 243 ; 536 2432 ; 536 2532 ; 935-5 ; 935-8 ; 935 76 ; 935 77 ; 935 78 ;
Abstract
A novel method for conjugating haptens, ligands or luminescent labels to polynucleotides has been developed. This method involves the formation of a mixed anhydride, followed by reaction of the mixed anhydride intermediate with a nucleophilic group-containing polynucleotide in a DMF/water solvent system. The resulting compound finds usefulness especially in the gene probe area.