The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 1997
Filed:
May. 18, 1995
Applicant:
Inventors:
Soren E Bjo slashed.rn, Lyngby, DK;
Kjeld Norris, Hellerup, DK;
Viggo Diness, Charlottenlund, DK;
Leif No slashed.rskov-Lauritsen, K.o slashed.ge, DK;
Niels D Christensen, K.o slashed.venhavn, DK;
Claus Bregengaard, Hellerup, DK;
Fanny Norris, Hellerup, DK;
Lars C Petersen, H.o slashed.rsholm, DK;
Assignee:
Novo Nordisk, Bagsvaerd, DK;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
530324 ; 530303 ; 530350 ;
Abstract
The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.