The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 1997
Filed:
Apr. 28, 1995
Shoichi Tokuda, Osaka, JP;
Kazuhisa Ninomiya, Osaka, JP;
Yasuhiro Fukushima, Osaka, JP;
Shigeyuki Watanabe, Osaka, JP;
Mitsuru Ochiai, Saitama, JP;
Mutsuo Okumura, Saitama, JP;
Yuko Hosokawa, Saitama, JP;
Itto Denko Corporation, Osaka, JP;
Nikken Chemicals Co., Ltd., Tokyo, JP;
Abstract
A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10% by weight of a monoglyceride off fatty acid having 6 to 8 carbon atoms and at least 5% by weight off isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50% by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine.