The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 1997
Filed:
Aug. 02, 1995
Applicant:
Inventors:
J William Lown, Edmonton, CA;
Ronald G Micetich, Sherwood Park, CA;
Assignees:
Synphar Laboratories, Inc., Alberta, CA;
Taiho Pharmaceutical Co., Ltd., Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ; C07K / ;
U.S. Cl.
CPC ...
514422 ; 548518 ; 514 18 ; 514 19 ; 530331 ; 530329 ; 530330 ;
Abstract
Oligopeptide antiretroviral agents are represented by formula (I), wherein A is a moiety bearing a positive charge and of a size which avoids steric inhibition of binding of said compound to nucleic acid sequences associated with the cellular activity of retroviruses; R.sub.1 is a moiety derived from a dicarboxylic acid; Hew is a five-membered heterocyclic moiety; y and z are independently 0, 1, 2 or 3; and x is 0 or 1. These compounds exhibit antiretroviral activity, especially against Human Immunodeficiency Virus (HIV). ##STR1##