The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 1997
Filed:
Nov. 12, 1993
Applicant:
Inventor:
Alan M Gewirtz, Philadelphia, PA (US);
Assignee:
The University of Pennsylvania, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C07H / ; C12Q / ;
U.S. Cl.
CPC ...
4351723 ; 435-6 ; 435 911 ; 435 913 ; 435 9133 ; 435 914 ; 4353201 ; 435375 ; 514 44 ; 536 231 ; 536 241 ; 536 243 ; 536 2431 ; 536 2433 ; 536 245 ; 536 251 ; 536 253 ; 536 2432 ;
Abstract
Antisense oligonucleotides specific for the vav proto-oncogene inhibit the proliferation of malignant, but not normal, myeloid cells. The oligonucleotides are therefore useful in the treatment of leukemias, in particular, as bone marrow purging agents. The vav antisense oligonucleotides also selectively inhibit the formation of erythroid cell colonies without effect on megakaryocyte and granulocyte/macrophage colony formation. The oligonucleotides are therefore useful in treating disorders characterized by an elevated hematocrit due to overproduction of erythrocytes.