The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 1997
Filed:
Nov. 17, 1994
Applicant:
Inventors:
Ta-Sen Chou, Indianapolis, IN (US);
Laurie M Poteet, Zionsville, IN (US);
Douglas P Kjell, West Lafayette, IN (US);
Assignee:
Eli Lilly and Company, Lilly Corporate Center, IN (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ;
U.S. Cl.
CPC ...
536 2711 ; 536 2712 ; 536 2721 ; 536 276 ; 536 278 ; 536 2781 ; 536 281 ; 536 283 ; 536 284 ; 536 285 ; 536 2852 ; 536 2853 ; 536 2855 ; 536 2854 ;
Abstract
A stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides by reacting a concentrated alpha- or beta-anomer enriched 2 -deoxy-2,2-difluorocarbohydrate or 2-deoxy-2 -fluorocarbohydrate with at least a molar equivalent of a nucleobase derivative in a high boiling inert solvent.