The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 1997
Filed:
Mar. 15, 1995
Applicant:
Inventors:
Ira H Pastan, Potomac, MD (US);
David J Fitzgerald, Silver Springs, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
514 12 ; 514-2 ; 530403 ; 530825 ; 530350 ; 530351 ; 4353201 ; 4351723 ; 43525233 ; 4352523 ; 435 691 ; 435 693 ; 435 697 ; 930200 ; 4241921 ; 4241931 ; 4242361 ;
Abstract
This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.