The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 1997
Filed:
Sep. 26, 1995
Jiri Michalsky, deceased, late of Olomouc, CS;
Jiri Hrbata, Olsany, CS;
Jiri Krepelka, Praha, CS;
Milan Melka, Hradec Kralove, CS;
Milan Miko, Bratislava, CS;
Milan Hruby, Olomouc, CS;
Milan Ferenc, Olomouc, CS;
Eva Skacelova, Hnevotin, CS;
Irena Kejhova, Praha, CS;
Rzena Reichlova, Praha, CS;
Anna Kargerova, Praha, CS;
Jitka Sediva, Praha, CS;
Alois Kolonicny, Pardubice, CS;
Josef Urbanec, Hradec Kraalove, CS;
VUFB a.s, Praha, CS;
Abstract
##STR1## New 6-[X-(2-hydroxyethyl)aminoalkyl]-5,11-dioxo-5,6-dihydro-11H-indeno[-1,2-c] isochinoline derivatives represented by general formula (I), in which X stands for the number of carbon atoms from 0 to 5 in aminoalkyl group situated on nitrogen atom in position 6 of the indenoisochinoline fundamental structure, their salts with inorganic and organic acids and their derivatives were described. Antitumorously effective indenoisochinoline derivatives are most preferably prepared by the process in which the indeno[1,2-c]isocoumarine and/or 1-methoxy-2-(2-methoxycarbonylphenyl)-1-inden-3-one, respectively, comprises reacting with N-(hydroxyethyl)alkylen diamine in a medium of suitable aprotic solvent, preferably dimethylformamide, and at increased temperature. Another process for the preparation comprises reacting 6-(X-chloroalkyl)-5,11-dioxo-5,6-dihydro-11H-indeno[1,2-c]isochinolines with 2-aminoethanol in suitable solvent, preferably dimethylformamide, in the presence of anhydrous potassium carbonate. New compounds, their derivatives and salts are useful for the preparation of drugs and compositions for the treatment of malignant neoplasias in mammals.