The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 1997
Filed:
Aug. 18, 1994
Allan L Goldstein, Bethedsa, MD (US);
Mirela O Fagarasan, Washington, DC (US);
The George Washington University Medical Center, Washington, DC (US);
Abstract
A method of treating septic shock in a mammal by preventing in vivo polymerization of actin in the mammal. An actin antipolymerizer such as thymosin .beta..sub.4 (T.beta..sub.4) is administered to the mammal so as to treat septic shock in the mammal. The amount of T.beta..sub.4 administered is sufficient to reduce levels of IL-1.alpha., TNF.alpha., PAF, Tx.beta..sub.2 and/or 6-keto-PGF.sub.1 .alpha. in the blood of the mammal. Also disclosed is a method of preventing septic shock in a mammal following endotoxin introduction in the mammal by administrating an actin antipolymerizer such as T.beta..sub.4.