The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 1997
Filed:
Jun. 01, 1995
Applicant:
Inventors:
Norbert Hauel, Schemmerhofen, DE;
Berthold Narr, deceased, late of Biberach, DE;
Uwe Ries, Biberch, DE;
Jacobus C van Meel, Mittelbiberach, DE;
Wolfgang Wienen, Biberach/Rissegg, DE;
Michael Entzeroth, Warthausen, DE;
Assignee:
Dr. Karl Thomae GmbH, Biberach an der Riss, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514381 ; 548250 ; 548254 ; 5483054 ; 5483057 ; 548153 ; 548217 ; 548181 ; 5142222 ; 5142345 ; 514248 ; 514258 ; 514261 ; 514322 ; 514338 ; 514307 ; 514314 ; 514367 ; 514375 ; 514394 ; 514303 ; 514365 ; 514397 ; 514398 ; 514399 ; 544-3 ; 544139 ; 544132 ; 544236 ; 544262 ; 544264 ; 546118 ; 546152 ; 546139 ; 546199 ; 5462734 ;
Abstract
Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: