The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 1996
Filed:
Feb. 20, 1996
Applicant:
Inventors:
David R Allen, Oak Brook, IL (US);
Scott Jenkins, San Francisco, CA (US);
Loraine Klein, Streamwood, IL (US);
Robert Erickson, Des Plaines, IL (US);
Diane Froen, Hoffman Estates, IL (US);
Assignee:
The Monsanto Company, St. Louis, MO (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
546146 ; 546147 ; 546116 ; 546 97 ;
Abstract
Methods for preparing (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide ('tic-c'), and converting tic-c to (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide ('tic-d') are disclosed. The initial step in the formation of tic-c involves the phosgenation of a substituted tetrahydroisoquinoline to form an N-carboxy anhydride. Tic-d is used as an intermediate in the synthesis of known compounds having pharmaceutical activity.