The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 1996
Filed:
Aug. 20, 1993
Applicant:
Inventors:
Robert R Garrity, Middletown, MD (US);
Peter L Nara, Frederick, MD (US);
Jaap Goudsmit, Amsterdam, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12P / ; C12N / ; C07K / ;
U.S. Cl.
CPC ...
435 693 ; 4351723 ; 4353201 ; 4241881 ; 4242071 ; 4242081 ; 514-2 ; 530350 ; 530395 ;
Abstract
The present invention provides a composition that can be administered to a mammal to cause immunoprotection in the mammal against a pathogenic organism that has an immunodominant epitope. The composition includes a modified form of the antigen in which the immunodominant epitope is located. In this modified form, the immunodominant epitope is immunodampened by any of a number of techniques. Examples of immunodampening techniques include addition of N-linked glycosylation sites, change of the net charge on the epitope, and substitution with a tolerated sequence. The composition also includes a pharmacologically acceptable carrier.