The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 1996
Filed:
May. 24, 1994
Applicant:
Inventors:
Robert A Lazarus, Millbrae, CA (US);
Mark Hurle, Bridgeport, PA (US);
Stephen Anderson, Princeton, NJ (US);
David B Powers, Somerset, NJ (US);
Assignee:
Rutgers, The State University of New Jersey, Piscataway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435190 ; 435189 ; 435 691 ; 4351723 ; 4353201 ; 4352523 ; 43525233 ; 536 232 ; 930240 ; 935 10 ; 935 14 ;
Abstract
Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.