The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 1996
Filed:
Jan. 14, 1994
Applicant:
Inventors:
James M Mason, Wallingford, CT (US);
Scott P Kennedy, Southington, CT (US);
Seth A Fidel, Mount Kisco, NY (US);
Assignee:
Alexion Pharmaceuticals, Inc., New Haven, CT (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12P / ; C07H / ;
U.S. Cl.
CPC ...
4351721 ; 4352402 ; 4353201 ; 435 691 ; 4351723 ; 4352351 ; 536 231 ; 536 234 ; 536 2372 ; 536 241 ;
Abstract
Retroviral vector particles are provided which contain: 1) oncoretroviral gag, pol, and env proteins, including an oncoretroviral gag capsid protein which has been mutated so as to contain a nuclear localization signal (NLS) sequence; and 2) at least one exogenous gene. The particles can be used to transduce non-proliferating cells, including stem cells and neurons. The presence of the NLS sequence allows the at least one exogenous gene to enter into the nucleus of a target cell, thus allowing integration of the gene into the genome of the target cell.